Exploring the Genotype Networks of Human Variation
In a recently published paper (Dall’Olio et al, 2014), we described a new method to look at genome variation based on the concept of genotype networks.
Genotype networks are described extensively in the group “The origins of Evolutionary Innovations” by Andreas Wagner, and they provide a method to estimate the robustness of a phenotype to mutations, and its ability of its underlying genotypes to evolve towards different phenotypes.
The data from this study are also available as a UCSC tracks. Click on this link to load them in the UCSC browser, or use this suffix (db=hg19&hubUrl=http://bioevo.upf.edu/~gdallolio/genotype_space/hub.txt) to add them to any other genome browser url.
Reference: Dall’Olio GM, Bertranpetit J, Wagner A, Laayouni H. Human genome variation and the concept of genotype networks. PLoS One. 2014 Jun 9;9(6):e99424. doi: 10.1371/journal.pone.0099424. eCollection 2014. PubMed PMID: 24911413; PubMed Central PMCID: PMC4049842. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099424